Sure Screening for Gaussian Graphical Models

We propose {graphical sure screening}, or GRASS, a very simple and computationally-efficient screening procedure for recovering the structure of a Gaussian graphical model in the high-dimensional setting. The GRASS estimate of the conditional dependence graph is obtained by thresholding the elements of the sample covariance matrix. The proposed approach possesses the sure screening property: with very high probability, the GRASS estimated edge set contains the true edge set. Furthermore, with high probability, the size of the estimated edge set is controlled. We provide a choice of threshold for GRASS that can control the expected false positive rate. We illustrate the performance of GRASS in a simulation study and on a gene expression data set, and show that in practice it performs quite competitively with more complex and computationally-demanding techniques for graph estimation

Worldwide genetic variation of the IGHV and TRBV immune receptor gene families in humans.

The immunoglobulin heavy variable (IGHV) and T cell beta variable (TRBV) loci are among the most complex and variable regions in the human genome. Generated through a process of gene duplication/deletion and diversification, these loci can vary extensively between individuals in copy number and contain genes that are highly similar, making their analysis technically challenging. Here, we present a comprehensive study of the functional gene segments in the IGHV and TRBV loci, quantifying their copy number and single-nucleotide variation in a globally diverse sample of 109 (IGHV) and 286 (TRBV) humans from over a 100 populations. We find that the IGHV and TRBV gene families exhibit starkly different patterns of variation. In addition to providing insight into the different evolutionary paths of the IGHV and TRBV loci, our results are also important to the adaptive immune repertoire sequencing community, where the lack of frequencies of common alleles and copy number variants is hampering existing analytical pipelines

DTER: Schedule Optimal RF Energy Request and Harvest for Internet of Things

We propose a new energy harvesting strategy that uses a dedicated energy source (ES) to optimally replenish energy for radio frequency (RF) energy harvesting powered Internet of Things. Specifically, we develop a two-step dual tunnel energy requesting (DTER) strategy that minimizes the energy consumption on both the energy harvesting device and the ES. Besides the causality and capacity constraints that are investigated in the existing approaches, DTER also takes into account the overhead issue and the nonlinear charge characteristics of an energy storage component to make the proposed strategy practical. Both offline and online scenarios are considered in the second step of DTER. To solve the nonlinear optimization problem of the offline scenario, we convert the design of offline optimal energy requesting problem into a classic shortest path problem and thus a global optimal solution can be obtained through dynamic programming (DP) algorithms. The online suboptimal transmission strategy is developed as well. Simulation study verifies that the online strategy can achieve almost the same energy efficiency as the global optimal solution in the long term

China’s Response to Green Development: The Theoretical Characteristics and Significance of the “Two Mountains” Theory

The severe ecological situation has become a global issue, which concerns the fate of mankind. At present, in order to comply with the trend of green development, change the development mode and build an ecological civilization-oriented country, the “two mountains” theory was conceived. The theory establishes the ecological goal of a Better Life, has a distinct ecological consciousness, and coalesces the dialectical wisdom of Marxist eco-philosophy. It is a new height of The Communist Party of China’s ecological civilization theory. Therefore, sorting out the historical logic of the birth of the “two mountains” theory and examining its essential provisions are of certain value and significance for deepening the understanding of the relationship between human beings and nature, steadily promoting economic ecology and ecological economization, and opening up new horizons for the study of Marxist Eco-philosophy